Xalatan® is a prostaglandin F analogue.
How Does Xalatan® Work?
Xalatan® is a prostanoid selective FP receptor agonist that reduces the intraocular pressure. Xalatan® is thought to lower the intraocular pressure by increasing the out flow of the fluid inside the eye (aqueous humor) through the trabecular meshwork and uveoscleral tissue. In clinical studies of patients with open angle glaucoma with an average starting intraocular pressure of 24-25 mmHg, the average pressure lowering effect of Xalatan® was 6-8 mmHg.
Reasons for Use of Xalatan®
Xalatan is indicated for use in open angle glaucoma, ocular hypertension and secondary glaucoma due to its intraocular pressure lowering effects.
Side Effects for Xalatan®
Xalatan® can cause increase or change in pigmentation of tissues with melanin pigment. The most often reported areas of increased pigmentation have occurred in the iris and eyelids. The pigmentation continues to progress as long as the person is using the medication. This change in pigmentation may be permanent.
Xalatan® has been shown to cause changes in eyelashes with increased length, thickness, darkness, and number of lashes.
Xalatan® should be used with caution in people with active inflammation in the eye.
Xalatan® should be used with caution in people who are at risk for macular edema. Macular edema and cystoid macular edema has been reported in some people using Xalatan®.
Xalatan® contains a preservative called benzalkonium chloride, which may be absorbed by the soft contact lenses. Contact lenses should not be inserted for at least fifteen minutes after installation of Xalatan®.
Xalatan® should be used in caution in pregnant women as there are no well controlled studies of use during pregnancy.
Studies have shown that precipitation occurs when eye drops containing thimerosal are mixed with Xalatan®. If you are using any other eye drops containing thimerosal, you should not use Xalatan® within five minutes of those drops.
Adverse Reactions Using Xalatan®
Xalatan® can cause redness of the eye (conjunctival hyperemia), growth of eyelashes, increased pigmentation, blurred vision, burning and stinging, itching, foreign body sensation, superficial punctate keratitis (irritation of the cornea), and red eyelids. Red eyes or hyperemia caused discontinuation of Xalatan® less than 1 % of the time.
Less common adverse reactions are dry eyes, excessive tearing, eye pain, lid pain, lid swelling and photophobia.
Still less common adverse reactions are conjunctivitis, double vision (diploplia), and eye discharge.
Systemic adverse reactions were upper respiratory infection (cold or flu), muscle, joint, or back pain, rash or allergic reaction, and chest pain (angina).
Overdosage Associated With Xalatan®
Other than possible eye irritation, there is no available information on overdosage.
Administration and Strength of Xalatan®
The recommended dosage is one drop instilled into the affected eye or eyes once daily at bedtime. It has been shown that using more than once a day can actually decrease the effectiveness of the medication.
How is Xalatan® Supplied?
Xalatan® is supplied in an ophthalmic dispensing bottle with a turquoise top in 2.5mLs. If you have unopened bottles store them in a refrigerator. Once you start using the medication, you no longer need to store it in the refrigerator.