What is Viroptic®?
Viroptic® is an antiviral drug used for the topical treatment of epithelial keratitis caused by herpes simplex virus. The chemical name is ?,?,?-trifluorothymidine.
How Does Viroptic® Work?
Viroptic® interferes with DNA synthesis in cultured mammalian cells. Its antiviral mechanism of action is not completely known clinically. Clinical studies have shown a better than 90% response to treatment as evidenced by corneal re-epithelialization within the 14 day treatment period. The clinical efficacy of Viroptic® in the treatment of stromal keratitis and uveitis due to herpes simplex or other ophthalmic infections caused by vaccinivirus or adenovirus have not been established in well-controlled clinical studies.
Reasons for Use of Viroptic®
Viroptic® is indicated for the treatment of primary and recurrent epithelial keratitis due to herpes simplex virus (types 1 and 2).
Contraindications for Viroptic®
Viroptic® is contraindicated for patients with hypersensitivity reactions or chemical intolerance to Viroptic®.
Side Effects and Precautions for Viroptic®
Viroptic® should only be used in patients with a diagnosis of herpes keratitis.
Viroptic® may cause irritation of the conjunctiva and cornea.
Viroptic® has been shown to cause mutagenic, DNA-damaging and cell-transforming activities in various in vitro test systems, and clastogenic activity in Vicia faba cells. The significance of these tests is not clear. There exists the possibility that mutagenic agents may cause genetic damage in humans.
Viroptic® should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. There are no adequate or well controlled studies in pregnant women.
Viroptic® should not be used for nursing mothers unless the benefits justify the potential risks.
Viroptic® used in patients below age six has not been studied.
Overdosage Associated With Viroptic®
Viroptic® overdosage by ocular use is unlikely.
Administration and Strength of Viroptic®
Viroptic® is instilled into the affected eye, one drop every two hours while awake for a maximum of nine drops per day until the epithelium has healed. It is used for an additional seven days, one drop every four hours after re-epthelialization. Administration of Viroptic® for more than twenty one should be avoided due to possible ocular toxicity.
How is Viroptic® Supplied?
Viroptic® Ophthalmic Solution 1.0% is supplied in an ophthalmic dispensing bottle, 7.5mL.