What is Travatan Z®?
Travatan Z® is a synthetic F2? analogue with intraocular pressure lowering activity.
How Does Travatan Z® Work?
Travatan Z® is thought to lower intraocular pressure by increasing the outflow of the fluid inside the eye (aqueous humor) by increasing the outflow of fluid through the trabecular meshwork and uveoscleral channels. In clinical studies of patients with open angle glaucoma with an average starting intraocular pressure of 25-27 mmHg, the average pressure lowering effect of Travatan Z® was 7-8 mmHg.
Reasons for Use of Travatan Z®
Travatan Z® is indicated for use in open angle glaucoma, ocular hypertension, and secondary glaucoma due to its intraocular pressure lowering effects.
Side Effects for Travatan Z®
Travatan Z® can cause increase or change in pigmentation of tissues containing melanin. The most often reported areas of increased pigmentation have occurred in the iris and eyelids. The pigmentation continues to progress as long as the person is using the medication. This change in pigmentation may be permanent.
Travatan Z® has been shown to cause changes in eyelashes with increased length, thickness, and number of lashes.
Travatan Z® should be used with caution in people with active inflammation in the eye.
Travatan Z® should be used with caution in people who are at risk for macular edema. Macular edema has been reported in some people using Travatan Z®.
Travatan Z® should be used with caution in pregnant women as there are no well controlled studies of use during pregnancy.
Adverse Reactions Using Travatan Z®
Travatan Z® can cause redness of the eye, growth of eyelashes, increased pigmentation, and ocular itching. Approximately 3% of people using Travatan Z® discontinued using it due to redness of the eye.
Less common adverse reactions are dry eyes, changes in vision, inflammation of the eyelids (blepharitis), irritation of the cornea (superficial punctate keratitis), pain, and red eyelids.
Still less common adverse reactions are eye conjunctivitis, light sensitivity, lid margin crusting, and conjunctival hemorrhage.
Non ocular adverse events were allergy, anxiety, cold/flu symptoms, and muscular pain.
Overdosage Associated With Travatan Z®
There is no available information on overdosage.
Administration and Strength of Travatan Z®
The recommended dosage is one drop instilled into the affected eye or eyes once daily at bedtime. It has been shown that using more than once a day can actually decrease the effectiveness of the medication.
How is Travatan Z® Supplied?
Travatan Z® is supplied in ophthalmic dispensing bottles with turquoise tops in two sizes; 2.5mL and 5.0mL.