What is Prolensa ™?
Prolensa is a nonsteroidal anti-inflammatory (NSAID) topical ophthalmic drug.
How Does Prolensa Work?
Prolensa is thought to work by decreasing the synthesis of prostaglandin by inhibiting cyclooxygenase (COX) 1 and 2. Prostaglandin has been shown to be the mediator of inflammation causing vasodilation, breakdown of the blood-aqueous barrier, increased vascular permeability, and leukocytosis.
Reasons for Using Prolensa
Prolensa is indicated for the treatment of postoperative inflammation and pain in patients after cataract surgery.
Contraindications for Prolensa
None
Precautions and Warnings for Prolensa
Sulfa Allergy
Prolensa contains sodium sulfite and may cause allergic type reactions in people allergic to sulfa including anaphylactic and life threatening reactions.
Slow or Delayed Healing
Prolensa may slow or delay healing.
Cross-Sensitivity
There is a potential cross-sensitivity to acetylsalicylic acid, phenylacetic acid derivatives, and other NSAIDs.
Increased Bleeding Time
Prolensa may potentially increase bleeding time secondary to interference with platelet aggregation.
Keratitis and Corneal Reactions
Prolensa may cause keratitis. Prolensa can cause epithelial breakdown, corneal thinning, corneal erosion, corneal ulceration, and /or corneal perforation. Prolensa should be used with caution in patients who are at risk of corneal complications with complicated ocular surgeries. Prolensa should be discontinued in patients with corneal changes.
Contact Lenses
Prolensa should not be instilled while wearing contact lenses. Prolensa should be instilled ten minutes before insertion or after removal on contact lenses.
Use During Pregnancy
Because of the known effects of NSAIDs on the fetal cardiovascular system, Prolensa should be avoided during late pregnancy.
Nursing Mothers
Prolensa should be used with caution in nursing mothers.
Pediatric Use
Prolensa has not been studied in patients under age eighteen.
Side Effects for Prolensa
- Anterior chamber inflammation
- Foreign body sensation
- Eye pain
- Photophobia or light sensitivity
- Blurred vision
Administration and Strength of Prolensa
Prolensa 0.07% is instilled into the surgical eye one time a day beginning one day prior to surgery and continued for fourteen days following surgery.
How is Prolensa Supplied?
Prolensa is supplied in a sterile 7.5 mL white ophthalmic dispensing bottle with a grey cap with 1.6mL or 3 mL of medication.
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