What is Moxeza™?
Moxeza™ is a 8-methoxy fluoroquinolone anti-infective agent with a diazabicyclononyl ring at the C 7 position.
How Does Moxeza™ Work?
The anti-infective activity results from the inhibition of the topoisomerase II and topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the replication, transcription, and repair of bacteria DNA. Topoisomerase IV is an enzyme known to have a major role in DNA in bacterial cell division.
Reasons for Using Moxeza™
Moxeza™ is indicated for the treatment of bacterial conjunctivitis caused by susceptible bacteria:
Most Staphylococcus strains
Contraindications for Moxeza™
Moxeza™ is contraindicated in people who are hypersensitive to quinolones or to other components of Moxeza™.
Side Effects and Precautions for Moxeza™
Moxeza™ is intended for topical use only.
Prolonged use as with other anti-infectives may cause an over-growth of non-susceptible bacteria and fungi.
People should not wear contact lenses if the person has an infection.
Pregnant women should use Moxeza™ only if the potential benefits outweigh the risks as there are no adequate studies for use in pregnant women.
Nursing mothers should use Moxeza™ with caution as it has not been measured in human breast milk.
Moxeza™ has not been studied in children under age of four months.
Long-term studies in animals to determine the carcinogenic potential of Moxeza™ have not been performed.
The most frequently reported side effects occurred in 1-2 % of patients:
Administration and Strength of Moxeza™
The recommended dosage of Moxeza™ is one drop in the infected eye or eyes two times a day for seven days. It comes in a strength of 0.5%.
How is Moxeza™ Supplied?
Moxeza™ is supplied in a sterile ophthalmic dispensing 4mL bottle filled with 3mL of Moxeza™.