What is Lotemax®?
Lotemax® is a sterile anti-inflammatory corticosteroid suspension for topical ocular use.
How Does Lotemax® Work?
Corticosteroids inhibit the inflammation caused by a variety of inciting agents, injuries, and surgery. They inhibit edema, fibrin deposition, fibroblast proliferation, deposition of collagen, capillary dilation, leukocyte migration, and scarring. Corticosteroids are thought to act by induction of phospholipase A and inhibitory proteins. This decreases the production of prostaglandins and leukotrienes which are mediators of inflammation.
Reasons for Using Lotemax®
Lotemax® is indicated for the treatment of inflammation of the eye such as the conjunctiva, cornea and anterior portion of the eye, allergies, herpes zoster eye conditions, iritis, uveitis, and certain posterior portions of the eye.
Lotemax® is indicated in the treatment of ocular inflammation following ocular surgery.
Contraindications for Lotemax®
Lotemax® is contraindicated in most cases of herpes simplex keratitis of the cornea, fungal diseases of the eye, bacterial conjunctivitis, vaccine, and varicella. It is contraindicated in anyone known to be hypersensitive to corticosteroids or other ingredients of this product.
Side Effects and Precautions for Lotemax®
If the symptoms do not improve after two days the patient should be re-examined.
If Lotemax® is used for longer than 10 days the patient should have their eye pressure checked as prolonged used can cause elevated intraocular pressure.
Care should be used not to contaminate the tip of the bottle by making contact with the eye.
Secondary fungal and bacterial infections may occur with prolonged use and care should be taken.
Long term studies have not been performed in regards to its carcinogenic effects.
Pregnant women should only use Lotemax® if the potential benefits outweigh the risks of using Lotemax®
Nursing mothers should not use Lotemax® unless the potential benefits outweigh the risks of using Lotemax®
Prolonged use of corticosteroids can cause a decrease in the immune system resulting in secondary infections.
Prolonged use of corticosteroids may lead to thinning of the cornea and sclera which could lead to perforation of the eye.
Lotemax® should not be instilled into eye while a contact lens is on the eye.
Lotemax® can cause an elevation of the intraocular pressure leading to the development of glaucoma and loss of vision with prolonged use.
Corticosteroids can cause posterior subcapsular cataracts with long term use.
Ocular Side Effects Occurring in 5-10% of Patients:
Blurred vision, burning, dry eyes, foreign body sensation, redness, chemosis, itching, watering, and photophobia (light sensitivity).
Ocular Side Effects Occurring in Less Than 5% of Patients:
Conjunctivitis, corneal changes, eyelid redness, pain, discomfort, keratoconjunctivitis, and uveitis.
Non-Ocular Side Effects Occurring in 15% of Patients:
Headache, rhinitis, and pharyngitis.
Administration and Strength of Lotemax®
The usual dosage is one drop in the affected eye or eyes four times a day. The dosage may be changed according to the level of inflammation by the eye doctor. It comes in a strength of 0.5%.
How is Lotemax® Supplied?
Lotemax® is supplied in a sterile ophthalmic dispensing bottle of the following sizes: 2.5mL, 5mL, 10mL, and 15mL.