What is Ilevro?
Ilevro is a sterile, nonsteroidal and anti-inflammatory ophthalmic suspension topical medication prodrug.
How Does It Work?
Ilevro penetrates the cornea and is converted by eye tissue hydrolases into amfenac which is a nonsteroidal anti-inflammatory drug. The mechanism of action of nepafenac and amfenac is thought to be by inhibiting the action of prostaglandin production.
Reason for Using
Ilevro is indicated for the treatment of pain and inflammation in association with a patient having cataract surgery.
Ilevro is contraindicated in patients with a prior history of hypersensitivity to any of its ingredients or to any other nonsteroidal anti-inflammatory medications or NSAIDs.
Precautions or Warnings
Increased Bleeding Times
As with other NSAIDs, there is the potential for increased bleeding times secondary to its interference with thrombocyte aggregation. It is recommended that Ilevro be used with caution in patients with known bleeding problems and/or who are taking medications that prolong bleeding.
As with other NASIDs, Ilevro may decrease or slow the healing response in patients. The use this medication and corticosteroids together may decrease the healing response even further.
As with other NSAIDs, Ilevro may cause keratitis or corneal disease. In some instances, there may be corneal breakdown, corneal ulceration, corneal erosion, corneal thinning, or corneal perforation.
Contact Lens Wear
Ilevro should not be instilled into the eye while wearing contact lenses.
Use in Pregnant and Nursing Women
There are well-controlled studies in pregnant or nursing women. Ilevro should not be used unless the potential benefits outweigh the risks.
Use in Children
Ilevro has not been studied in children below 10 years of age.
Ocular Side Effects
Side Effects in 5 to 10 % of Patients
- Decreased vision
- Capsular opacification
- Increased intraocular pressure
- Sticky sensation
- Foreign body sensation
Side Effects in 1 to 5 % of Patients
- Conjunctival edema
- Corneal edema
- Eyelid crusting
- Red eye
- Ocular pain and discomfort
- Ocular pruritus
- Vitreous detachment
Non-Ocular Side Effects
Side Effects in 1 to 4 % of Patients
Administration and Dosage
Ilevro should be started 1 day before cataract surgery and for 14 days following surgery one drop per day in the operated eye.
How is it Supplied?
Ilevro is supplied in a sterile, white, oval, eye drop dispensing bottle. There is 1.7 mL of medication in a 4ml bottle.