What is Elestat®?
Elestat® is a sterile topical ophthalmic solution containing epinastine which is an antihistamine.
How Does Elestat® Work?
Elestat® is a H1 receptor antagonist which inhibits the release of histamine from mast cells in the body. This release is what is responsible for the symptoms related to allergies. Elestat® also inhibits ?1, ?2, and 5-HT2 receptors. Elestat® does not have central nervous systems side effects as it does not cross the blood brain barrier.
Reasons for Use of Elestat®
Elestat® is indicated for the treatment of ocular itching secondary to allergic conjunctivitis.
Contraindications for Elestat®
Elestat® is contraindicated in patients sensitive to Elestat® or any of its ingredients.
Side Effects and Precautions for Elestat®
Ocular Side Effects
Ocular side effects occurring in 1 to 10% of patients include;
Burning sensation after instillation
Non-Ocular Side Effects
Non-Ocular Side Effects in 10% of patients;
Upper respiratory infections or cold symptoms
Non-Ocular Side Effects in 1 to 3% of patients;
Elestat® is for ocular topical use only.
Elestat® should only be used in pregnant women if the benefits outweigh the potential risks as there are not adequate controlled studies in pregnant women.
Elestat® may be excreted in human milk and therefore should not be used unless the benefits outweigh the potential risks.
Use in Children
Safety in children under age three has not been studied and therefore should be used only if the benefits outweigh the potential risks.
Administration and Strength of Elestat®
Elestat® comes in a strength of 0.05% and is administered one drop in the affected eye or eyes two times per day.
Elestat® is supplied in sterile white opaque topical ophthalmic dispensing bottles of 10mL size with a fill of 5mL.