What is Durezol™?
Durezol™ is a topical ocular corticosteroid used for the treatment of inflammation and pain.
How Does Durezol™ Work?
Durezol™ or corticosteroids inhibit the inflammatory response to numerous incidents which may slow or delay healing.
Reasons for Use of Durezol™
Durezol™ is used to reduce the inflammation associated with ocular surgery.
Contraindications for Durezol™
Durezol™ is contraindicated in most active viral diseases of the cornea (including epithelial herpes simplex keratitis or dendritic keratitis) and conjunctiva. It is also contraindicated in mycobacterial infection of the eye and fungal diseases of the eye.
Side Effects and Precautions for Durezol™
Intraocular Pressure Elevation (IOP)
Prolonged use of corticosteroids may cause an increase in IOP resulting in glaucoma damage to the optic nerve with loss of visual acuity and visual field loss. If it is used longer than 10 days, the IOP should be monitored.
The use of corticosteroids can cause the formation of posterior subcapsular cataracts.
The use of corticosteroids may slow or delay healing after ocular surgery. This may result in thinning of the cornea or sclera, formation of blebs, and perforations have occurred. Careful monitoring should be done with prolonged use of Durezol™.
Prolonged use of corticosteroids may suppress the immune response and thus increase the risk of secondary eye infections. In acute infections, the corticosteroids could mask the severity of the infection or cause the infection to become worse.
The use of corticosteroids in patients with a history of herpes simplex should be used with extreme caution. Prolonged use of corticosteroids can prolong the course and may exacerbate the severity of a viral infection.
The use of prolonged corticosteroids may make a person prone to a fungal infection. A fungal infection should be considered in any corneal ulceration where a corticosteroid has been used.
Adverse Events Using Durezol™
Ocular adverse events occurring in 5-15 % of patients include corneal edema, conjunctival redness or hyperemia and edema, eye pain, photophobia, posterior subcapsular cataracts, anterior chamber flare and cells, and blepharitis.
Ocular adverse events occurring in 1-5 % of patients include reduced vision, superficial punctate keratitis, eye inflammation and iritis.
Ocular adverse events occurring in < 1 % of patients include pain with instillation of the medication, corneal pigmentation and striae, episcleritis, itching, eyelid irritation, foreign body sensation, tearing, macular edema, and uveitis.
Many of these events may be related to the actual surgical procedure.
Administration and Strength of Durezol™
Instill 1 drop into the affected eye 4 times a day for the first 2 weeks after eye surgery, 2 times a day for 2 weeks and taper according to the response.
How is Durezol™ Supplied?
Durezol™ is supplied in ophthalmic dispensing bottles with a pink top in 5.0mL size bottles.