What is Bromday™?
Bromday™ is a topical, nonsteroidal, anti inflammatory drug (NSAID) for ocular use.
How Does Bromday™ Work?
The mechanism of action is thought to be due to its ability to block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.Prostaglandins have been shown to be mediators of certain kinds of intraocular inflammation.
Reasons for Use of Bromday™
Bromday™ is a nonsteroidal anti-inflammatory drug indicated for the treatment of postoperative inflammation and reduction of ocular pain in patients who have undergone cataract surgery.
Side Effects and Precautions for Bromday™
Sulfite Allergic Reactions
Bromday™ contains sodium sulfite, a sulfite that may cause allergic-type reactions including anaphylactic reactions and life threatening or less severe episodes in certain susceptible people.
Slow or Delayed Healing
All topical nonsteroidal anti-inflammatory drugs may slow or delay healing. Concomitant use with topical steroids may increase the potential healing problems.
Increased Bleeding Time
With some NSAIDs there exists the potential for increased bleeding time due to interference with platelet aggregation. There have been reports that ocularly applied DSAIDs may cause increased bleeding of ocular tissues in conjunction with ocular surgery.
Keratitis and Corneal Reactions
Use of Bromday™ may result in keratitis. In some susceptible patients, continued use of Bromday™ may result in epithelial breakdown, corneal thinning, corneal erosion, corneal ulceration, or corneal perforation. Using Bromday™ in patients with complicated ocular surgeries, corneal denervation, corneal epithelial defects, diabetes mellitus, ocular surface diseases, rheumatoid arthritis, or repeat ocular surgeries may be at risk for corneal complications.
Precautions for Bromday™
Bromday™ should not be used while wearing contact lenses.
Bromday™ should be only used during pregnancy if the potential benefits outweigh the risks.
Bromday™ should be used with caution in nursing women.
Bromday™ safety or efficiency in patients under 18 has not been established.
Adverse Events Using Bromday™
The most common adverse events reported using Bromday™ include: abnormal sensation in the eye, redness of the eye (hyperemia), eye irritation ( burning and stinging), eye pain, purities, headache, and iritis. These were reported in 2-7% of patients.
Administration and Strength of Bromday™
Instill one drop into the affected eye or eyes once daily beginning 1 day prior to surgery, continued on the day of surgery, and through the first 14 days post surgery. The strength of Bromday™ is 0.09 %.
How is Bromday™ Supplied?
Bromday™ 0.09% is supplied in a white eye drop dispensing bottle with a grey cap 1.7ml in a 7.5 mL bottle.