What is Alrex®?
Alrex® is a sterile anti-inflammatory corticosteroid for topical ocular use.
How does Alrex® Work?
Corticosteroids inhibit and used to treat edema, fibrin deposition, capillary dilation, leukocyte migration, fibroblast proliferation, deposition of collagen, and scar formation. Alrex® is thought to act by the induction of phospholipase A2. It inhibits the mediators of inflammation.
Reasons for Using Alrex®
Alrex® is indicated for the treatment of seasonal allergic conjunctivitis.
Contraindications for Alrex®
Alrex® is contraindicated in most cases of herpes simplex keratitis of the cornea, bacterial infections of the eye, fungal infections of the eye, vaccine, and Varicella. It is also contraindicated in anyone known to be allergic to corticosteroids.
Side Effects and Precautions for Alrex®
Patients should be re-evaluated if not improving within 2 days.
If Alrex® is used for more than 10 days, the intraocular pressure should be checked.
Fungal infections may occur with long term use of corticosteroids.
Prolonged use of Alrex® can suppress the immune system and secondary infections may occur. Patients should be monitored.
Alrex® should only be used in patients with a history of ocular herpes infections with great caution.
Alrex® should be used with caution in patients wearing contact lenses. It should not be instilled while the contact is on the eye.
Pregnant women should only use Alrex® if the potential benefits outweigh the risks as there are not any long term studies in pregnant women.
Nursing mothers should use Alrex® with caution as there are not adequate studies to show its safety.
Ocular Side Effects in 5-15%:
Blurred vision, burning, dry eyes, Chemosis, foreign body sensation, tearing, discharge, redness, itching, and light sensitivity (photophobia).
Ocular Side Effects in 5% or Less:
Conjunctivitis, redness of the eyelids, corneal changes, keratoconjunctivitis, pain, discomfort, and uveitis.
Non-Ocular Side Effects in Less Than 15 %:
Headaches, rhinitis, and pharyngitis
Administration and Strength of Alrex®
Alrex® comes in strength of 0.2%. Alrex® is to be administered one drop in the affected eye or eyes four times a day unless directed differently by your eye doctor.
How is Alrex® Supplied?
Alrex® is supplied in a sterile topical ophthalmic dispensing bottle in 5 mL and 10mL sizes.