What is Zylet®?
Zylet® is a combination of a corticosteroid (anti-inflammatory) and tobramycin (antibiotic) in a sterile multiuse bottle for ophthalmic use.
How Does Zylet® Work?
Corticosteroids inhibit the inflammatory reaction to inciting agents or diseases. It is thought to work by the induction of phospholipase A2. It is thought corticosteroids control the production of prostaglandins and leukotrienes which are mediators of inflammation.
Tobramycin is an antibiotic that kills susceptible bacteria.
Reasons for Using Zylet®
Zylet® is indicated in the treatment of inflammatory diseases of the conjunctiva, cornea, and anterior portion of the eye. It can be used to treat allergies, herpes zoster keratitis, iritis, and certain other infections. It is used in inflammatory diseases where there is a bacterial infection or a risk of a bacterial infection.
Contraindications for Zylet®
Zylet® is contraindicated in people with viral infections of the cornea and eye especially herpes simplex keratitis. It is also contraindicated fungal infections and mycobacterial infections. Anyone who is allergic to any of the components of Zylet® should not use it.
Side Effects and Precautions for Zylet®
Prolonged use of corticosteroids can lead to elevated intraocular eye pressures. This can lead to the development of glaucoma and the possibility of blindness if the patient is not monitored while using it.
Prolonged use of corticosteroids may decrease the immune response in the patient. This can lead to secondary infections.
Prolonged use of corticosteroids may lead to thinning of the cornea or sclera with possible perforation.
The patient should have their eye pressure checked if they have used the medications for 10 or more days.
As with other antibiotics, over growth of non-susceptible bacteria may occur with prolonged use.
Pregnant women should only use Zylet® if the potential benefits outweigh the risks as there are no adequate studies concerning its safety in pregnant women.
Nursing women should only use Zylet® if the potential benefits outweigh the risks as there are no adequate studies concerning its safety in nursing women.
Adverse Events Using Zylet®
Ocular Adverse Events
Adverse events occurring in greater than 20 % were red eyes or injection and superficial punctate keratitis.
Adverse events in approximately 10 % were increased intraocular eye pressure and burning or stinging on instillation of the medicine.
Adverse events occurring in less than 4 % were blurred vision, discharge, itching, photophobia, corneal deposits, and pain.
Non-Ocular Adverse Events
Headaches were reported in nearly 15 % of patients.
Administration and Strength of Zylet®
Shake before using Zylet®. One drop instilled into the affected eye or eyes four times a day. Zylet comes in a strength of loteprednol etabonate 0.5% and tobramycin 0.3%.
How is Zylet® Supplied?
Zylet® is supplied in a white sterile ophthalmic dispensing multiuse bottle.
2.5 mL in a 7.5mL bottle
5 mL in a 7.5mL bottle
10mL in a 10 mL bottle
