Lumigan is a synthetic prostamide analog with intraocular pressure lowering activity.
How Does Lumigan® Work?
Lumigan® is thought to lower intraocular pressure by increasing the outflow of the fluid inside the eye (aqueous humor) by increasing the outflow of fluid through the trabecular meshwork and uveoscleral channels. In clinical studies of patients with open angle glaucoma with an average starting intraocular pressure of 26 mmHg, the average pressure lowering effect of Lumigan® was 7-8 mmHg.
Reasons for Use of Lumigan®
Lumigan® is indicated for use in open angle glaucoma, ocular hypertension, and secondary glaucoma due to its intraocular pressure lowering effects.
Side Effects for Lumigan®
Lumigan® can cause increase or change in pigmentation of tissues with melanin. The most often reported areas of increased pigmentation have occurred in the iris and eyelids. The pigmentation continues to progress as long as the person is using the medication. This change in pigmentation may be permanent.
Lumigan® has been shown to cause changes in eyelashes with increased length, thickness, and number of lashes. This medication is now being used as a cosmetic product sold under the name Latisse®.
Lumigan® should be used with caution in people with active inflammation in the eye.
Lumigan® should be used with caution in people who are at risk for macular edema. Macular edema has been reported in some people using Lumigan®.
Lumigan® contains a preservative called benzalkonium chloride, which may be absorbed by soft contact lenses. Contact lenses should not be inserted for at least fifteen minutes after installation of Lumigan®.
Lumigan® should be used with caution in pregnant women as there are no well controlled studies of use during pregnancy.
Adverse Reactions With Using Lumigan®
Lumigan® can cause redness of the eye, growth of eyelashes, increased pigmentation, and ocular itching.
Less common adverse reactions are dry eyes, changes in vision, inflammation of the eyelids (blepharitis),cataract, irritation of the cornea (superficial punctate keratitis), and red eyelids.
Still less common adverse reactions are eye discharge, tearing, light sensitivity (photophobia), allergic conjunctivitis, and conjunctival edema. Less than 1 % reported iritis (inflammation inside the eye).
Overdosage Associated With Lumigan®
There is no available information on over dosage.
Administration and Strength of Lumigan®
The recommended dosage is one drop instilled into the affected eye or eyes once daily at bedtime. It has been shown that using more than once a day can actually decrease the effectiveness of the medication.
How is Lumigan® Supplied?
Lumigan® is supplied in ophthalmic dispensing bottles with turquoise tops in three sizes; 2.5 mL, 5mL, and 7.5mL.